Aclasta: Zolendronic acid for Osteoporosis

Aclasta is an Osteoporosis drug sold in Europe. In the United states it is distributed under the name Reclast. ( If you wish to read the pages about the USA form, just click on Reclast )

Both of these are forms of zoledronic acid, an Osteoporosis drug that is taken only once a year. It is given by an infusion in your doctor's office. (Note the bottle; no pills.)

Many people really like having their Osteoporosis treatment only once a year. No need to remember daily or weekly pills. With Aclasta (Reclast) you only need to go to your health care provider's office once a year for your Osteoporosis treatment.

Many people really like not having to remember a daily or weekly pills. There is nothing to remember with this drug. Most doctors' office staff are more than willing to keep track and let you know when it is time for you to come in for your annual infusion.

Now if you are considering it, you will want to know a bit more about this particular Osteoporosis drug. . You especially want to find out if there is anything that could pose a problem for you so read on....

Novartis is the drug company that manufactures Aclasta

Novartis is one of the largest pharmaceutical companies in the world.  After a  three year study called Pivotal Fracture Trial  showed that this drug increased bone strength and it reduced fractures of the hip, spine and other areas such as wrists, arms, legs or ribs, the drug was approved for use. Note: There is a claim  that this treatment is the only treatment that has been shown to reduce fractures at ALL the key sites (hip, spine, wrists, arms, legs and ribs).

As for spinal fractures that often cause dowagers humps, you may want to know that in May 2007 the New England Journal of Medicine reported that a study involving more than 7,700 women showed that treatment with this drug reduced the risk of spine fractures by 70% (a known cause of dowagers hump)  and it reduced hip fractures by 41%.

The reduction in spine fractures for the three years of the study was as follows: 60% in year one; 71% in year two and 70% in year three.  Again, those are significant numbers! - especially when we consider that bone loss in the spine usually lead to kyphosis (or dowagers hump)  - a difficult and unsightly condition. 


To read more about this medication and/or to print out material to take with your to your health care provider go to:  Aclasta, Reclast Research Studies

NOTE: A spokesperson for Novatis said this drug: "has shown significant efficacy in protecting women against fractures in all the common osteoporotic fracture sites, while demonstrating a favorable safety profile, It is our hope that this innovative once-yearly dosing regimen will have a positive impact on the management of this potentially devastating condition." 

Novartis says that this medication:

   "is indicated for treatment of osteoporosis in postmenopausal women. In patients with a recent low-trauma hip fracture," It "reduces the incidence of new clinical fractures". And it:

  • "is indicated for treatment of osteoporosis in men at increased risk of fracture, including those with a recent low-trauma hip fracture."
  • "is indicated for treatment of osteoporosis associated with long-term systemic glucocorticoid therapy in postmenopausal women and in men with increased risk of fracture".
  • and finally, "Aclasta is indicated for the treatment of Paget's disease of the bone."

Many in the health care community believe that once a year infusions are an effective remedy for the main problem with daily, weekly or monthly medications. The problem with daily or even monthly medications is that many people just stop taking the medications for Osteopenia and Osteoporosis! (This failure to take one's medication called 'non-compliance' by the medical community and non-compliance with pills for bone loss is high.)


Side effects

Side effects Since this drug is sold under various names in different countries, the same side effects would apply  under its other name, Reclast. In fact, if you live in the United States, the Novartis site directs your to a  page about Reclast.

Novartis is careful to mention the possibility of Osetonecrosis with any of the bisphosphonates. They also state:

"Disturbances of mineral metabolism must be treated before starting therapy. Patients must be adequately supplemented with calcium and vitamin D. A single dose of Aclasta should not exceed 5 mg and infusion time should be no less than 15 minutes."

A study published in March of 2013, showed more serious side effects: Acute kidney injury. You can read a summary of that study by clicking this link to the Journal of Oncology Practice.

If you want to read about other potential side effects and a list of conditions that would preclude using this drug go to:  scroll down this page to Aclasta, Reclast Side Effects

Other medications for low bone density can be found at:                              Osteopenia and Osteoporosis medications

If you are interested in learning about the natural treatments for building stronger bones, go to Natural Osteopenia, Osteoporosis Treatments

NOTE: This web site offers science based information, not medical advice. For medical advice you need to consult a licensed medical practitioner.

I have a FREE monthly newsletter with updates about Osteopenia and Osteoporosis treatments. It also offers encouragement for women and men with the condition. Click here to subscribe to the Osteopenia3 updates newsletter

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SPECIAL NOTE: If you have used Aclasta and would like to leave a comment about your experience, please use the Testimonial form below. Please put the word Aclasta at the opening of your comments so I know what your comments are about. (I use the same form for comments on all pages.) If you do not put Aclasta, Zolendronic acid at the top of your response, I will not be able to add your comments to this page.

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I had aclasta on a Tuesday afternoon that night I started shaking and felt like I had been transported to the Antartic. Muscle pain in the back and legs …

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