Aclasta Osteoporosis information

Aclasta Osteoporosis information. Aclasta is an Osteoporosis drug distributed in Europe and in Australia. In the United States, Acalsta is distributed under a different name, Reclast. This is the exact same drug as Aclasta. It just has a different name. 

Some facts about Aclasta.  Aclasta is a form of zolendronic acid which is a bisphosphonate, a drug that slows the rate at which 'old bone' is removed.  Aclasta is administered by an infusion in your doctor's office. You go to the office. They set up an IV which brings Aclasta into your vein. Then you go home. Done. No daily or weekly pills to remember.  Many patients prefer this medication because it is a once a year treatment. You just make an appointment, go to your doctor's office, have your infusion and then you are done til next year.

Osteoporosis treatment with Aclasta (Reclast) appeals to those of use who prefer not to be taking daily or weekly pills. There is nothing to remember with this drug! (And most doctors' office staff are willing to keep track of your treatment date and  call you when it is time for you to make an appointment and come in for your annual infusion.

OK. If you are considering Aclasta for treating your Osteoporosis, you probably want to know a bit read on. 

Who makes Aclasta ?

Novartis,  one of the largest pharmaceutical companies in the world, is the company that makes Aclasta.   They  developed this drug and did all the necessary research studies. 

After one study,  The Pivotal Fracture Trial, showed that Aclasta both increased bone strength and reduced fractures of the hip, spine and other areas such as  wrists, arms, legs and/or ribs, it was approved for use by those with documented bone loss. 

Note:  These studies showed that Aclasta  appeared to be effective in reducing fractures, which is the real reason why anyone treats Osteoporosis. No one wants a fracture because their bones have become thinner, weaker because of age or other things. (See: All Causes of Osteopenia, Osteoporosis )

When Aclasta was approved, it was the only treatment that had been shown to reduce fractures at ALL the key sites where Osteoporosis fractures usually occur: hips, spine, wrists, arms, legs and ribs. 

If you are concerned about having any of the small spinal fractures that cause dowagers humps, (back hump) the New England Journal of Medicine reported in May 2007 that a study involving more than 7,700 women, showed that treatment with Aclasta reduced the risk of spinal fractures by 70%  AND it also reduced hip fractures by 41%.

The reduction in spinal fractures for the three years of the study was as follows: 60% reduction in year one; 71% in year two and 70% in year three. Those are significant numbers! -- especially when we consider that bone loss in the spine usually leads to kyphosis (or dowagers hump)  - an unsightly and often debilitating condition. 

More Aclasta Osteoporosis information:

Novatis, the company manufacturing Aclasta,  states in their Aclasta Osteoporosis information that the drug: 

      "has shown significant efficacy in protecting women against fractures in all the            common osteoporotic fracture sites, while demonstrating a favorable safety                profile. It is our hope that this innovative once-yearly dosing regimen will have a          positive impact on the management of this potentially devastating condition." 

Also, in the same Aclasta Osteoporosis information,  Novartis says that Aclasta  "is indicated for treatment of osteoporosis in postmenopausal women. In patients with a recent low-trauma hip fracture".. and that this drug.. "reduces the incidence of new clinical fractures".   

If you are considering getting this annual drug infusion, you may be interested in knowing that Aclasta is:

  • also  "indicated for treatment of osteoporosis in men at increased risk of fracture, including those with a recent low-trauma hip fracture."
  • "indicated for treatment of osteoporosis associated with long-term systemic glucocorticoid therapy in postmenopausal women and in men with increased risk of fracture" and 
  • "Aclasta is indicated for the treatment of Paget's disease of the bone."

Other advantages of Aclasta. Many in the health care community believe that once a year infusions are the helpful for patients because they offer a remedy for the inconvenience of daily, weekly or monthly Osteoporosis medications.  Also annual infusions eliminate one of the main problems of daily or monthly medications - that many people just stop taking their prescribed medication!                                           (The failure to take medication is called 'non-compliance' by the medical community and it has been shown that Osteoporosis medication non-compliance with daily or weekly pills is high. Aclasta reduces the non-compliance rate.)

Alcasta Osteoporosis information: Side effects

Aclasta Osteoporosis information: Side Effects. Note: Since this drug is sold under various names in different countries, these same side effects apply to its other forms such as, Reclast.  (In fact, if you live in the United States, the Novartis site will direct you to a page about Reclast, not Aclasta)

Since this is a bisphosphonate drug Novartis is careful to mention in their Aclasta Osteoporosis information that is a possibility of developing Osetonecrosis . The company also states in its Aclasta information that:

"Disturbances of mineral metabolism must be treated before starting therapy.        Patients must be adequately supplemented with calcium and vitamin D. A single      dose of Aclasta should not exceed 5 mg and infusion time should be no less than 15 minutes." 

Serious side effects: A study published in March of 2013, showed a serious side effect with this drug: Acute kidney injury. If you want to  read a summary of that study click this link to it: Journal of Oncology Practice.

If you want to read about other potential side effects as well as a list of medical conditions that would preclude you from using this drug go to: Aclasta Information: Reclast side effects 

There is even more Aclasta Osteoporosis information, including some you can print out to take with your to your visit with your health care provider, at:  Aclasta, Reclast Research Studies                                                                     


If you have used this drug and  want to leave a comment about your experience on this Aclasta Osteoporosis information page, please scroll down and use the form provided.  Thanks.  

End of Aclasta Osteoporosis Information. 

Information about other medications for low bone density can be found at:          Osteopenia and Osteoporosis medications

If you are interested in learning about the natural treatments for building stronger bones, go to Natural Osteopenia, Osteoporosis Treatments

NOTE: This web site offers science based information, such as the Aclasta information given above. The web site does not offer medical advice at any time. For medical advice you need to consult your licensed medical practitioner.

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Reader Comments received :

1. From Jeanne in Adelaide South Australia.

SPECIAL NOTE: If you have used Aclasta and would like to leave a comment about your experience, please use the  form below. Please be sure to put the word Aclasta at the beginning of your comment so I know which page you are commenting on. (I use the same form for all pages.) If you do not put Aclasta information or  Zolendronic acid information at the top of your response, I shall not be able to add your comments to this page. Thanks.

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Jean in Adelaide, South Australia Not rated yet
On 23 January 2018 I had my first infusion of Aclasta. I felt fine for around 15 hours afterwards and then developed the flu like symptoms I was warned …

Aclasta reaction Not rated yet
I had aclasta on a Tuesday afternoon that night I started shaking and felt like I had been transported to the Antartic. Muscle pain in the back and legs …

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