New directions in pharmeceuticals

I just found an article published in Arthritis Research Therapy describing new pharmaceutical research aimed at 'molecular structure' for bone building. (Warning: Some of the next few paragraphs is in technical language.)

" Recent studies indicate new possibilities for case finding, such as in vivo structural analysis of bone microarchitecture, and new molecular targets to rebalance bone remodeling." This leads to two potential drugs:

1. Catepsin K-inhibitors: Caepsin K stimulate bone loss so the idea is to find drugs to inhibit Catepsin K. Their words: "Cathepsin K is the most abundant cysteine protease expressed in the osteoclast and is believed to be instrumental in the bone matrix degradation necessary for bone resorption. Cathepsin K inhibitors represent a novel target for developing agents to treat osteoporosis and other disorders characterized by increased bone resorption"

2. Antisclerostin antibodies - sclerostin slows bone formation in older persons. So there is a push to find drugs that will reduce sclerostin.

In their words: "The discovery that the Wnt signaling is a major pathway in osteoblast activity has resulted in a revolution in our understanding of the molecular mechanisms that are involved in bone formation. Preclinical studies have shown that sclerostin has a pivotal role as a negative regulator of bone formation in the aging skeleton and, furthermore, suggest that antibody-mediated inhibition of sclerostin represents a promising new therapeutic approach for the anabolic treatments of bone-related disorders, such as postmenopausal osteoporosis [180]. treatment of bone-related disorders, such as postmenopausal osteoporosis."

Exciting new herb studies

Crocin

(NOTE: there is a crocin (paracetamol) listed on Glaxo-Sline web site as an over-the-counter-pain-medication but try as I might, I can find NO evidence that this is the same thing as the herb Crocin.

Researches found the Crocin, a constituent of saffron, is beneficial against OVX-induced osteoporosis in rats.(surgical induced post menopausal osteoporosis). The major findings of the study are as follows: first, treatment with higher crocin doses significantly improved the bone mass, bone strength, bone microarchitecture, and bone turnover in OVX-induced osteoporotic rats; second, the highest crocin dosage exerted the best protective effect against osteoporosis....(and finally) crocin significantly attenuated oxidative stress in serum and bone tissue, indicating that crocin's beneficial effect on bone is attributed at least partially to crocin's antioxidative effects. Taken together, these results suggest the potential role of crocin as a natural alternative for postmenopausal osteoporosis management. nausea, dizziness, and limb pain."

NOTE: Crocin ,the herb, is available through the PRODUCTS page of the OSTEOPENIA3.COM web site. Go to the PRODUCTS PAGE of the web site: https://www.osteopenia3.com/Osteopenia-products.html ______________ SUPPLEMENTS are at the top of the page. Just before the banner for Life Extension is a company KALYX....click on it and put Crocin in their search box. You will find they offer 60 vegetarian caps for a moderate price. (NOTE: Although Amazon sells saffron, they do not sell Crocin by itself so they are not a good source.). I have shopped at Kalyx in the past and have been pleased with their service and quality.

Where we are headed in 2015 and.....

My goal for 2015 is to have a full section on the web site about HERBS FOR BONE BUILDING. At present I have a list of at least 8 that have been found useful and now that more are available for purchase in the West it seems a good idea to include them on the site. .

Finally, I want to thank you for reading this newsletter. It is a privilege to be able to use my skills for the good of others.

I also want to thank those of you who support this work either by using the DONATE BUTTON on the web site or by buying your products or booking your travel through the PRODUCTS page on the Ostepenia3.com web site. As you know those companies give me a small percent of anything purchased through those links. And yes, the income makes a difference.

So, be well. Be happy. And I shall be in touch come 2015.