Strontium fructose Osteoporosis

Strontium fructose may be a new effective treatment for postmenopausal Osteoporosis. Ever since the discovery that strontium increases the density of bones (1910) there has been an ongoing study of this mineral by researchers concerned  with Osteoporosis and Osteopenia.


We know that there have been some serious cardiac side effects of the
pharmaceutical form strontium ranelate.  We also know the a pharmaceutical company in the United States has been working on another form: strontium malonate.

But the journal Acta Pharmacologica Sinica published a study in 2012 by Chinese researchers showing the "protective effects of strontium fructose 1,6-diphosphate  (FDP-Sr), a novel strontium salt  that combined fructose 1,6-diphosphate (FDP)  with strontium".

This is to me, exciting news.

Strontium fructose study

The study was done on eighty female Sprague-Dawley rats. Some  were  ovariectomized (OVX); others had sham operations.

" Three months later, the rats  were assigned to six groups (10 for each):
2.OVX control,
3. OVX+FDP-Sr (110mg per kg)
4. Ovx+FDP-Sr (220 mg per kg)
5. Ovx+FDP-SR (440 mg/kg)
6. OVX+strontium ranelate (SR, 180 mg/kg).

Drugs were administered orally to groups 3 - 6 for 3 months. "When the treatment  was terminated, the following parameters were assessed:
1.bone mineral density
2.biomechanical properties of the femur and lumbar vertebrae
3.trabecular histomorphology, serum phosphorus, calcium, bone-specific
alkaline phosphatase (B-ALP), tartrate-resistant acid phosphatase 5b (TRACP5b), N-telopeptide of type I collagen (NTx) and a series of markers for oxidative stress.
4.Receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG)
levels in serum were measured using ELISA and their gene expression levels.

Results?   "Treatment with FDP-Sr (220 or 440 mg/kg) or SR (180 mg/kg) significantly increased the BMD and improved the bone microarchitecture and bone strength in OVX rats." (italics mine)

There were some other positive chemical changes. You can
read them in the RESULTS section of the Strontium fructose Osteoporosis study.

But what isreally  encouraging is that the researchers concluded: "FDP-Sr may be an effective treatment for postmenopausal osteoporosis." (The link for the full study is above.)

Another study was published in 2013 by the European Journal Pharmacology " Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1,6-diphosphate on estrogen
 deficiency-induced osteoporosis in rats by GC/TOF-MS." Again the study was done by Chinese  scientists.

The abstract of this study stated:

"A novel strontium salt compound strontium fructose 1, 6-diphosphate (FDP-Sr) has  been proved to have highly effective for bone loss via dual effects of  stimulating bone formation and suppressing bone absorption. In the present study, metabolomic approach was used to identify and study potential biomarkers  associated with the effect and safety of FDP-Sr. . . . 

Some metabolites including homocysteine, arachidonic acid, alanine, and hydroxyproline, which significantly changed during osteoporosis progression could be effectively  reversed after FDP-Sr therapy. Of course some metabolites such as uric acid, glyceric acid, octadecadienoic acid, docosahexaenoic acid, oleic acid,
and hexadecanoic acid were not found to reverse significantly after
FDP-Sr administration.

These results delineated the FDP-Sr effects-related  metabolic alterations in the bone loss rats, suggesting that metabonomic analysis could provide helpful information on the new potential biomarkers relating to the mechanism of anti-osteoporosis action
 and side effects of  FDP-Sr against estrogen deficiency induced bone loss."  (The underlining indicates encouraging conclusion about this potential new drug.)

If and when it comes to market, I shall update this page.  Meantime you might want to mention it to your health care provider so s/he can be on the lookout for any new developments in your own country.

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