Ipriflavone Osteoporosis, Osteopenia

Ipriflavone Osteoporosis, Osteopenia. Dispensed as pharmaceutical drug in Japan, Italy and several other nations, it has not been approved as a drug in all countries.  In those countries where there is no Ipriflavone Osteoporosis pharmaceutical drug,  people buy it as a natural supplement in a  food store.

You can buy this in single doses OR you can buy calcium supplements with Ipriflavone in them. But before you do, I urge you to read more about it.

Basic information about using Ipriflavone Osteoporosis or Osteopenia

• What is ipriflavone?  It is a synthetic isoflavone that appears to inhibit your osteoclasts in the performance of bone resorption. (In this it is like a number of pharmaceutical drugs such as the bisphosphonates) It also appears to stimulate osteoblasts to build more bone. (This is a feature not found in most bisphosphonated.)           Most of the research about Ipriflavone Osteoporosis has been done in Japan and Italy.
•  Effectiveness in  preventing or reversing bone loss. At least one scientific study indicated that 600 mg a day may prevent bone loss and that it may increase bone mass in postmenopausalwomen.                                                      Another study of 474 post menopausal white women with  with normal or Osteopenic bone mineral density concluded that in dose of 500 mg a day, isoflaone had no significant benefit in bone density or on the number of fractures. There was a negative side effect of lymphocytopeni (see: below) in a significant number of the women.
• What is the normal dose? 600 mg. Some take 200 mg three times a day; others take 300 mg twice day.
• Are there any side effects?  In a trial where 132 women took ipriflavone over a 3 year period, 29 of the women developed a significant drop in lymphocytes, which are critical components on the immune system. It took these women almost 2 years before they returned to normal lymphocytes counts.                                                                                                                                          Any woman taking this drug or supplement, should have her lymphcytes measured on a regular basis by her physician.In at least one study it was shown that taking this flavone in addition to estrogen, increased the effect of estrogen in the uterus - thus raising some concern about cancer.              It is advised that anyone with kidney disease consult their health care provider before using Ipriflavone. A lower dose is recommended in kidney disease.The only other side effect reported has been mild stomach upset.
• What about drug interactions?

If you are taking any drug that is metabolized in the liver, such as Theophylline, tolbutamide, Dilantin (phenytoin), Coumadin (warfarin) Ipriflavone might change the levels of that drug in your body.  If you are on medication, do consult with your health care provider before using it.


As noted above, Ipriflavone might also increase the risk of uterine cancer if you are taking estrogen.

Again: You should not use this supplement/drug unless under medical supervision if you are taking any drug that suppresses the immune system eg. corticosteroids, methotrexate, or cyclosporine

If you are going to buy Ipriflavone as a supplement you will find that Amazon offers several brands at reasonable prices