Bioidentical hormone replacement therapy
Bioidentical hormone replacement therapy (BHRT) or natural
hormone therapy uses hormones that are molecularly identical to
edogenous hormones. These include estrone, stradiol and progesterone as
well as testosterone, dehydroepiandrosterone and estriol.
The aim of such therapy is to replicate the natural levels of
these hormones. Proponents of BHRT see it as a panacea for diseases,
including Osteoporosis, instead of the mere
relief of menopausal symptoms.
The use of progesterone , a Bioidentical hormone
replacement therapy for the prevention and treatment of Osteopenia and
Osteoporosis has been suggested by John R. Lee M.D since the 1990's.
You can read about Dr. John Lees's
recommendations and scientific research about it at
Bioidentical hormone replacement therapy : progesterone
Scientific evidence for Bioidentical hormone replacement
What do the scientific studies say about this Bioidentical hormone replacement? There have been several studies published since 2007. Here is a summary of their findings:
- 2007. Journal General Internal Medicine. July 2007.
"Bioidentical Hormones for Menopausal Hormone Therapy: Variation on a
Theme Adriane Fugh-Berman, MDcorresponding author and Jenna Bythrow, MS
candidate. ABSTRACT: BACKGROUND. Progesterone creams and natural or
bioidentical compounded estrogen preparations
are being promoted to consumers as safe alternatives to conventional
menopausal hormone therapy and as health-promoting tonics. No reliable
data support these claims.
SAFETY Natural hormones, including estradiol, estriol, estrone,
and progesterone, can be expected to have the same adverse event
profile as conventional menopausal hormone regimens.
SALIVARY HORMONE TESTS. Salivary tests may be used to persuade
asymptomatic consumers to use hormones (or symptomatic patients to use
higher doses than those needed to mitigate symptoms),
a practice that can be expected to result in adverse events.
- But in 2009 there was an article published that reviewed all published studies and came to a very different conclusion,
Postgrad Med. Jan. 2009 "The bioidentical hormone debate: are
bioidentical hormones (estradiol, estriol, and progesterone) safer or
more efficacious than commonly used synthetic versions in hormone
replacement therapy?" by K Holtorf ofHoltorf Medical Group, Inc.,
Torrance, CA 90505, USA. ABSTRACT: BACKGROUND: The use of bioidentical hormones,
including progesterone, estradiol, and estriol, in hormone
replacement therapy (HRT) has sparked intense debate. Of special
concern is their relative safety compared with traditional synthetic and
animal-derived versions, such as conjugated equine estrogens (CEE),
medroxyprogesterone acetate (MPA),
and other synthetic progestins. Proponents for bioidentical hormones
claim that they are safer than comparable synthetic and nonhuman
versions of HRT. Yet according to the
US Food and Drug Administration and The Endocrine Society, there is
little or no evidence to support claims that bioidentical hormones are
safer or more effective.
OBJECTIVE: This paper aimed to evaluate the evidence comparing
bioidentical hormones, including progesterone, estradiol, and estriol,
with the commonly used nonbioidentical
versions of HRT for clinical efficacy, physiologic actions on breast
tissue, and risks for breast cancer and cardiovascular disease.
METHODS: Published papers were identified from PubMed/MEDLINE,
Google Scholar, and Cochrane databases, which included keywords
associated with bioidentical hormones, synthetic hormones, and HRT.
Papers that compared the effects of bioidentical and
synthetic hormones, including clinical outcomes and in vitro results,
RESULTS: Patients report greater satisfaction with HRTs that
contain progesterone compared with those that contain a synthetic
progestin. Bioidentical hormones have some distinctly different,
potentially opposite, physiological effects compared
with their synthetic counterparts, which have different chemical
structures. Both physiological and clinical data have indicated that
progesterone is associated with a diminished risk for breast cancer,
compared with the increased risk associated with
synthetic progestins. Estriol has some unique physiological effects,
which differentiate it from estradiol, estrone, and CEE. Estriol would
be expected to carry less risk for breast cancer, although no randomized
have been documented. Synthetic progestins have a variety of negative
cardiovascular effects, which may be avoided with progesterone.
CONCLUSION: Physiological data and clinical outcomes demonstrate
that bioidentical hormones are associated with lower risks, including
the risk of breast cancer and cardiovascular disease, and are more
efficacious than their synthetic and animal-derived
counterparts. Until evidence is found to the contrary, bioidentical
hormones remain the preferred method of HRT. Further randomized
controlled trials are needed
to delineate these differences more clearly.
END of abstract about Bioidentical hormone replacement hormone replacement therapy
NOTE: I could post additional abstracts on this topic but this page would get much too long.
Because this is a fairly new therapy it is not often suggested, I think that
readers would be interested in reading about 'real life' experiences of
women who have used it.
If you have used bioidentical hormone
replacement therapy and would like to share your experience, you can do
so by using the form below. You might want to include why you chose
this therapy rather than one of the many others, how you felt during it
and what results you had.
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